| 00.0 | - | Betterton Route 292 | 47.2 | - | Cross route 13 (becomes Commerce Street - Smyrne) * |
| 03.6 | - | Becomes route 566 East (Still Pond) | 47.4 | - | Cross Main Street, continue on Commerce |
| 04.8 | L | Route 298 North | 48.3 | - | Becomes Route 6 West |
| 07.4 | L | Route 213 North | 56.2 | - | Cross MD/DE state line, becomes MD Route 291 West |
| 13.2 | - | Route 290 North (Galena) | 60.6 | - | Cross Route 313 (Millington) |
| 17.2 | - | Go under Route 301 overpass | 62.1 | - | Cross Route 301 |
| 17.5 | BL | Becomes 299 North | 73.9 | - | Cross Route 213 |
| 18.2 | R | Sassafras/Caldwell Road | 74.5 | R | Route 20 South |
| 20.4 | - | Cross MD/DE state line (Caldwell Corners) becomes VanDyke Green Spring Road | 81.5 | R | Route 21 South |
| 24.7 | - | Becomes Route 15 South | 84.7 | - | Tolchester Beach, return on Route 21 East |
| 27.7 | - | Becomes VanDyke Green Spring Road again | 85.5 | L | Bay Shore Road |
| 29.1 | R | Route 486 (not marked) | 89.6 | L | Route 298 North |
| 30.2 | - | Cross Route 6, becomes Main Street (Smyrna) | 99.7 | L | Route 292 North |
| 30.6 | L | Commerce Street | 102.6 | L | Route 292 North (Still Pond) |
| 30.7 | - | Cross Route 13, becomes 6 East * | 104.2 | - | Arrive Betterton Beach |
| 39.0 | - | Woodland Beach, Return to Smyrna by Route 6 West (Woodland Beach Road) | | | |